Zombie- I'm only including the brain eeeaating beasts out of courtesy because let's be honest here folks, zombies even a zombie horde doesn't bring much to the table. Even if you give them that "28 Days Later" super speed, all they have is their intensity. If they can get taken down quick with simple headshot/lawn mower decapitation, I don't see how they can hang with Vampires and Werewolves.
Vampire- Ah, the Twilight terror. Blessed with strength, shape shifting (bats, wolves, it don't matter), and a thirst for sangre rojo, the vampire is quite a nemesis. In the evening, he can regulate Warren G style, but let's just be honest here, in the daytime, totally helpless. Forced to sleep in the box, dreaming of The Harker Sisters, and totally exposed.
Werewolf- Don't let the Taylor Lautnerization of these ferocious beasts fool you, they don't play around. And while they only come out during a full moon, when they are at the height of their powers they are not be taken lightly, which is a polite way of saying they are not to be fucked with.
The Verdict: Lil bit of an upset here, I gotta go with the Werewolf, but not for the reasons you might think. Let me break it down and drop a lil something on you right here. Werewolves are the only creatures that have full mental capacity during the day, so while Vampires are sleeping, Werewolves are scheming. And yeah they only turn when the moon is full, but it's as simple as not inviting vampires inside. Give it up Wolfie, you're the champ.